Systemic Lupus Erythematosus (Sle) - Related Resources

Cochrane reviews

Cyclophosphamide might possibly be more effective in reducing symptoms of neuropsychiatric involvement in SLE compared with methylprednisolone but the evidence is insufficient Cyclophosphamide Versus Methylprednisolone for Treating Neuropsychiatric Involvement in Sle.
Combined with steroids, mycophenolate mofetil (MMF) appears to be as effective as cyclophosphamide in inducing remission in lupus nephritis, and is safer with a lower risk of ovarian failure Treatment of Lupus Nephritis.
Combined unfractionated heparin and aspirin appear to reduce pregnancy loss significantly in women with antiphospholipid antibody or lupus anticoagulant Prevention of Recurrent Miscarriage for Women with Antiphospholipid Antibody or Lupus Anticoagulant.
Dehydroepiandrosterone compared to placebo seems to have limited or no effect on disease activity with mild to moderate systemic lupus erythematosus, but it may slightly improve health-related quality of life Dehydroepiandrosterone (Dhea) for Systemic Lupus Erythematosus (Sle).
Fluocinonide cream seems to be more effective than hydrocortisone cream for discoid lupus erythematosus, although the evidence is insufficient. Hydroxychloroquine and acitretin may be as effective Drugs for Discoid Lupus Erythematosus.

Oral contraceptives appear not to increase the risk of flare, disease activity or thrombotic events in stable SLE Oral Contraceptives in Women with Systemic Lupus Erythematosus.
Discontinuing hydroxychloroquine medication in stabile systemic lupus erythematosus may increase the risk or relapse Hydroxychloroquine in the Treatment of Systemic Lupus Erythematosus.

Bertsias G, Ioannidis JP, Boletis J et al. EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics. Ann Rheum Dis 2008;67(2):195-205. [PubMed]
Bertsias GK, Ioannidis JP, Aringer M et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis 2010;69(12):2074-82. [PubMed]
Bertsias GK, Tektonidou M, Amoura Z et al. Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis 2012;71(11):1771-82. [PubMed]

Petri M, Orbai AM, Alarcón GS et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012;64(8):2677-86. [PubMed]
D'Cruz DP, Khamashta MA, Hughes GR. Systemic lupus erythematosus. Lancet 2007 Feb 17;369(9561):587-96. [PubMed]

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