Comment: The quality of evidence is downgraded by study quality (more than 20% loss to follow up in all trials and unclear allocation concealment in most of the studies) and by inconsistency (variability in results across studies).
A Cochrane review [Abstract] 1 included 7 randomized controlled trials; 6 assigned clusters and 1 randomized individuals. Sample sizes for the cluster-randomized trials ranged from 2157 to 15 614; the number of clusters ranged from 18 to 70. 4 trials took place in African countries, 2 in the USA, and 1 in England. 3 were based mainly in schools, 2 were in community settings, 1 took place during military training, and 1 was clinic-based.No significant difference between study groups for pregnancy (3 trials) or HIV (4 trials) was shown. Favorable effects were evident for some sexually transmitted infections (STI): Two trials showed a lower incidence of HSV-2 for the behavioral-intervention group compared to the usual-care group, however a moderate quality trial showed no difference. For syphilis and gonorrhea, a moderate quality trial showed no difference, while two low quality studies had some favourable effects.
Another cochrane review review [Abstract] 2 included 3 randomized controlled trials and a pilot study for one of the included trials. The interventions differed markedly: computer-delivered, individually tailored sessions; phone counseling added to clinic counseling; and case management plus a peer-leadership program. The latter study, which addressed multiple risks, showed an effect on contraceptive use. Compared to the control group, the intervention group was more likely to report consistent dual-method use, i.e., oral contraceptives and condoms. The reported relative risk was 1.58 at 12 months (95% CI 1.03 to 2.43) and 1.36 at 24 months (95% CI 1.01 to 1.85). The related pilot study showed more reporting of consistent dual-method use for the intervention group compared to the control group (P value = 0.06). The other two trials did not show any significant difference between the study groups in reported dual-method use or in test results for pregnancy or sexually transmitted infections at 12 or 24 months.
Date of latest search: 5 March 2014
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