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Evidence summaries

Low-Dose Aspirin for in Vitro Fertilisation

Low-dose aspirin is probably not effective for increasing live birth rate, or clinical pregnancy rate in women undergoing in vitro fertilisation. Level of evidence: "C"

A Cochrane review [Abstract] 1 included 13 studies with a total of 2 653 subjects. No significant differences were found between the treatment (aspirin 80-100mg/day) and control groups for any of the outcomes assessed; for live birth rate RR 0.91 (95% CI 0.72 to 1.15; 3 studies, n=1053), for clinical pregnancy rate RR 1.03 (0.91 to 1.17; 10 studies, n=2142), and for miscarriage rate RR 1.10 (0.68 to 1.77; 5 sudies, n=1497). No data were reported on adverse events related to aspirin treatment.

Comment: The quality of evidence is downgraded by imprecise results (few studies assessing live birth rate which is the most important outcome) and by heterogeneity in interventions (dosage, timing).

References

  • Poustie VJ, Dodd S, Drakeley AJ. Low-dose aspirin for in vitro fertilisation. Cochrane Database Syst Rev 2007 Oct 17;(4):CD004832 [Last assessed as up-to-date: 9 May 2016]. [PubMed]

Primary/Secondary Keywords