Bipolar Disorder (Manic-Depressive Disorder) - Related Resources

Cochrane reviews

There is insufficient evidence from randomised controlled trials regarding the use of oxcarbazepine in maintenance phase of bipolar illness, either in monotherapy or as an adjunctive treatment Oxcarbazepine in the Maintenance Treatment of Bipolar Disorder.
Omega-3 fatty acids might possibly be effective as an adjunctive treatment for depressive but not manic symptoms in bipolar disorder, but the evidence is insufficient Omega-3 Fatty Acids for Bipolar Disorder.
Olanzapine may prevent further mood episodes in patients who have responded to olanzapine during an index manic or mixed episode and who have not previously had a satisfactory response to lithium or valproate Olanzapine in Long-Term Treatment for Bipolar Disorder.
Oxcarbazepine might possibly have similar efficacy to more accepted medications for acute affective episodes in bipolar disorder, although the evidence is insufficient Oxcarbazepine for Acute Affective Episodes in Bipolar Disorder.
Haloperidol appears to be an effective treatment for acute mania Haloperidol Alone or in Combination for Acute Mania.

Grunze H, Kasper S, Goodwin G et al; WFSBP Task Force on Treatment Guidelines for Bipolar Disorders. The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders, part III: maintenance treatment. World J Biol Psychiatry 2004 Jul;5(3):120-35. [PubMed]
Yatham LN, Kennedy SH, O'Donovan C et al; Canadian Network for Mood and Anxiety Treatments. Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies. Bipolar Disord 2005;7 Suppl 3():5-69. [PubMed]
National Institute for Health and Clinical Excellence (NICE). Bipolar disorder: The management of bipolar disorder in adults, children and adolescents, in primary and secondary care. NICE Clinical Guideline 38, July 2006 http://guidance.nice.org.uk/CG38

Craddock N, Sklar P. Genetics of bipolar disorder. Lancet 2013 May 11;381(9878):1654-62
Phillips ML, Kupfer DJ. Bipolar disorder diagnosis: challenges and future directions. Lancet 2013;381(9878):1663-71. [PubMed]
Geddes JR, Miklowitz DJ. Treatment of bipolar disorder. Lancet 2013;381:1672-82.
BALANCE investigators and collaborators, Geddes JR, Goodwin GM, Rendell J, Azorin JM, Cipriani A, Ostacher MJ, Morriss R, Alder N, Juszczak E. Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial. Lancet 2010 Jan 30;375(9712):385-95. [PubMed].

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