Contraindicated in:
Use Cautiously in:
Exercise Extreme Caution in:
CV: hypotension, tachycardia, QT prolongation, ARRHYTHMIAS (INCLUDING TORSADES DE POINTES).
EENT: blurred vision, dry eyes.
GI: constipation, dry mouth.
Neuro: extrapyramidal reactions, abnormal EEG, anxiety, confusion, dizziness, excessive sedation, hallucinations, hyperactivity, mental depression, nightmares, restlessness, SEIZURES, tardive dyskinesia.
Resp: bronchospasm, laryngospasm.
Misc: chills, facial sweating, shivering.
Drug-Drug:
Drug-Natural Products:
Absorption: Well absorbed following IM administration. IV administration results in complete bioavailability.
Distribution: Appears to cross the blood-brain barrier and placenta.
Metabolism/Excretion: Mainly metabolized by the liver. Only 10% excreted unchanged by the kidneys.
Half-life: 2.2 hr.
(sedation)
ROUTE | ONSET | PEAK | DURATION* |
---|---|---|---|
IM, IV | 310 min | 30 min | 24 hr |
*Listed as duration of tranquilization; alterations in consciousness may last up to 12 hr.