Contraindicated in:
Use Cautiously in:
Neuro: headache.
Resp: hemoptysis.
CV: chest pain, QT interval prolongation.
GI: nausea, anorexia, HEPATOTOXICITY.
Derm: rash.
MS: arthralgia.
Drug-Drug:
Absorption: Absorption following oral administration is doubled by food.
Distribution: Unknown.
Protein Binding: >99.9%.
Metabolism/Excretion: Mostly metabolized (CYP3A4 enzyme system) and eliminated in feces, negligible renal excretion.
Half-life: 5.5 mo (terminal elimination half-life).