Contraindicated in:
Use Cautiously in:
CV: MYOCARDIAL INFARCTION, hypertension, angina pectoris, arterial spasm, intermittent claudication.
GI: abdominal pain, nausea, vomiting, diarrhea, polydipsia.
MS: extremity stiffness, muscle pain, stiff neck, stiff shoulders.
Neuro: leg weakness, numbness or tingling in fingers or toes , dizziness.
Misc: fatigue.
Drug-Drug:
Therapeutic Classification: vascular headache suppressants
Pharmacologic Classification: ergot alkaloids
Absorption: Unpredictably absorbed (60%) from the GI tract. Sublingual absorption is very poor.
Distribution: Crosses the blood-brain barrier and enters breast milk.
Protein Binding: 9398%.
Metabolism/Excretion: Highly metabolized (90%) by the liver. Some metabolites are active.
Half-life: 1.52.5 hours.