Contraindicated in:
Use Cautiously in:
EENT: ototoxicity (vestibular and cochlear).
GU: nephrotoxicity.
F and E: hypomagnesemia.
MS: muscle paralysis (high parenteral doses).
Misc: hypersensitivity reactions.
Drug-Drug:
Renal Impairment
Spectrum:
Absorption: Well absorbed after IM and intra-peritoneal administration. Negligible absorption when administered orally.
Distribution: Widely distributed throughout extracellular fluid; crosses the placenta; small amounts enter breast milk. Poor penetration into CSF.
Metabolism/Excretion: Excretion is >90% renal.
Half-life: 24 hr (increased in renal impairment).