Unlabeled Uses:
Contraindicated in:
Use Cautiously in:
CNS: weakness.
Derm: alopecia, hyperpigmentation.
Endo: gonadal suppression, oligospermia.
GI: HEPATOTOXICITY, anorexia, diarrhea, nausea, vomiting.
Hemat: MACROPHAGE ACTIVATION SYNDROME, anemia, leukopenia, thrombocytopenia.
Metab: hyperuricemia.
Misc: HEPATOSPLENIC T-CELL LYMPHOMA, SECONDARY MALIGNANCY, fever.
Drug-Drug:
Drug-Natural Products:
Absorption: Variably and incompletely (550%) absorbed after oral administration.
Distribution: Widely distributed throughout total body water.
Metabolism/Excretion: Metabolized by liver. Converted to inactive metabolite by thiopurine methyltransferase (TPMT); nucleotide diphosphatase [NUDT15] is also involved in inactivation process. Nearly 50% is excreted unchanged by the kidneys.
Half-life: Three phases 45 min, 2.5 hr, 10 hr.