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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), rash.

Endo: Grave's disease.

GI: autoimmune hepatitis, hepatotoxicity.

MS: polymyositis.

Neuro: depression ( in children), dizziness, Guillain-Barré syndrome, headache, insomnia.
Misc: immune reconstitution syndrome.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

Route/Dosage

Treatment-Nave Patients With HIV Infection

Combination Therapy With Cabotegravir for HIV Infection

US Brand Names

Edurant

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: non nucleoside reverse transcriptase inhibitors

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Unknown.

Protein Binding: 99.7%.

Metabolism/Excretion: Mostly metabolized by the liver by the CYP3A isoenzyme; 25% excreted in feces unchanged, <1% excreted unchanged in urine.

Half-life: 50 hr.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown4–5 hr24 hr

Patient/Family Teaching

Pronunciation

RIL-pi-vir-een