glycine

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Indications ⬇

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

REMS

Wound healing (topical)
Schizophrenia
Neuroprotection after acute ischemic stroke

Contraind./Precautions ⬆ ⬇

Contraindicated in:

None known.

Use Cautiously in:

Pregnancy and lactation (insufficient information).

Adv. Reactions/Side Effects ⬆ ⬇

GI: Nausea, abdominal discomfort, vomiting

Interactions ⬆ ⬇

Natural-Drug Products:

May worsen schizophrenia symptoms when taken with clozapine.

Natural-Natural Products:

None known.

Availability ⬆ ⬇

Powder: ^OTC
Capsules: ^OTC
Topical cream (10 mg glycine, 2 mg cysteine and 1 mg threonine per gram): ^OTC

Route/Dosage ⬆ ⬇

PO (Adults ): Schizophrenia-0.4–0.8 g/kg daily in divided doses.
SL (Adults ): Acute ischemic stroke-1–2 g/day started within 6 hrs after stroke onset.
(Adults ): Leg ulcers-Apply cream (containing 10 mg glycine per gram and other agents) at wound cleaning and dressing changes once or twice daily.

US Brand Names ⬆ ⬇

L-glycine, Athenon, Monazol, G salt

Action ⬆ ⬇

Non-essential amino acid that acts as an agonist at the glutamate receptor N-methyl-D-aspartate (NMDA).

Therapeutic effects:

Improved schizophrenia symptoms.
Neuroprotection.
Healing of leg ulcers.

Classifications ⬆ ⬇

Therapeutic Classification: wound/ulcer/decubiti healing agent, antipsychotics

Pharmacokinetics ⬆ ⬇

Absorption: Unknown.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
PO	unknown	unknown	unknown

Patient/Family Teaching ⬆ ⬇

Advise patient to take as directed and to notify health care professional if unexpected side effects occur.

Pronunciation ⬆

GLYE-seen