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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: rash, pruritus.

EENT: blurred vision.

Endo: hyperglycemia.

GI: abdominal cramps, constipation, diarrhea, flatus, heartburn, nausea, liver enzymes, altered taste, drug-induced hepatitis, dyspepsia, pancreatitis.

GU: erectile dysfunction.

MS: arthralgia, immune-mediated necrotizing myopathy, myopathy, myositis, RHABDOMYOLYSIS.

Neuro: headache, amnesia, confusion, dizziness, insomnia, memory loss, weakness.
Misc: hypersensitivity reactions.

Interactions

Drug-Drug:

Drug-Natural Products:

Drug-Food:

Availability

(Generic available)

Route/Dosage

Renal Impairment

US Brand Names

Altoprev, Mevacor

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: hmg coa reductase inhibitors (statin)

Pharmacokinetics

Absorption: Poorly and variably absorbed after oral administration.

Distribution: Crosses the blood-brain barrier and placenta.

Metabolism/Excretion: Extensively metabolized by the liver, most during first pass; excreted in bile and feces. 10% excreted unchanged by the kidneys.

Half-life: 3 hr.

Time/Action Profile

(cholesterol-lowering effect)

ROUTEONSETPEAKDURATION
PO, PO-ER2 wk4–6 wk6 wk

†After discontinuation.

Patient/Family Teaching

Pronunciation

LOE-va-sta-tin

Pill Image

lovastatin_195_8765.jpg