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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: palpitations, CARDIOVASCULAR COLLAPSE, hypertension, tachycardia.

Derm: diaphoresis.

GI: anorexia, dry mouth.

GU: dysuria.

Neuro: anxiety, nervousness, dizziness, drowsiness, excitability, fear, hallucinations, headache, insomnia, restlessness, SEIZURES, weakness.

Resp: respiratory difficulty.

Interactions

Drug-Drug:

Drug-Food:

Availability

(Generic available)

Route/Dosage

see Calculator

US Brand Names

Silfedrine Children's, Sudafed 12 Hour, Sudafed 24 Hour, Sudafed Children's, SudoGest, SudoGest 12 Hour

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: allergy, cold and cough remedies, nasal drying agents/decongestants

Pharmacologic Classification: adrenergics

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Appears to enter the CSF.

Metabolism/Excretion: Partially metabolized by the liver. 55–75% excreted unchanged by the kidneys (depends on urine pH).

Half-life: Children: 3.1 hr; Adults: 9–16 hr (depends on urine pH).

Time/Action Profile

(decongestant effects)

ROUTEONSETPEAKDURATION
PO15–30 minunknown4–6 hr
PO-ER60 minunknown12 hr

Patient/Family Teaching

Pronunciation

soo-doe-e-FED-rin