tirbanibulin

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: crusting, erosion/ulceration, erythema, flaking/scaling, swelling, vesiculation/pustulation

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

(Adults ): Apply sufficient amount of ointment to affected area (within a 100 cm² contiguous area) once daily for 5 consecutive days.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Acts as a microtubule inhibitor; however, mechanism for effect in actinic keratosis is unknown.

Therapeutic effects:

Classifications ⬆ ⬇

Therapeutic Classification:

Pharmacologic Classification: antimicrotubulars

Pharmacokinetics ⬆ ⬇

Absorption: Negligible systemic absorption following topical use.

Distribution: Unknown.

Metabolism/Excretion: Primarily metabolized in liver via the CYP3A4 isoenzyme and to a lesser extent by the CYP2C8 isoenzyme.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
Top	unknown	7 hr	unknown

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Advise patient to notify health care professional if local skin reactions (redness, flaking, scaling, crusting, swelling that is more severe) or if blisters, peeling, pus, ulcers, or breakdown of skin occurs.
Advise patient that the medication is not for ophthalmic use. Advise patients to avoid application around the eyes and transfer of the drug into the eyes and to the periocular area. If accidental exposure occurs, advise patients to flush eyes with water and seek medical care.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.