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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: QT interval prolongation, AORTIC ANEURYSM/DISSECTION, TORSADE DE POINTES.

Derm: photosensitivity, rash, STEVENS-JOHNSON SYNDROME.

Endo: hyperglycemia, hypoglycemia.

GI: diarrhea, nausea, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain, vomiting.

GU: vaginitis.

MS: arthralgia, myalgia, tendinitis, tendon rupture.

Neuro: agitation, anxiety, confusion, depression, dizziness , ELEVATED INTRACRANIAL PRESSURE (INCLUDING PSEUDOTUMOR CEREBRI), hallucinations, headache, insomnia, nightmares, paranoia, peripheral neuropathy, SEIZURES, SUICIDAL THOUGHTS, toxic psychosis, tremor.
Misc: (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS .

Interactions

Drug-Drug:

Drug-Food:

Availability

(Generic available)

Route/Dosage

Acute Bacterial Exacerbations of Chronic Bronchitis

Community-Acquired Pneumonia

Uncomplicated Skin/Skin Structure Infections

Uncomplicated Urethral and Cervical Gonorrhea

Nongonococcal Urethritis/Cervicitis

Mixed Infection of the Urethra and Cervix

Acute Pelvic Inflammatory Disease

Urinary Tract Infections

Prostatitis

Renal Impairment

US Brand Names

Floxin, Floxin Otic

Action

Therapeutic Effects:

Spectrum:

Classifications

Therapeutic Classification: anti-infectives

Pharmacologic Classification: Fluoroquinolones

Pharmacokinetics

Absorption: Well absorbed (98%) following oral administration.

Distribution: Widely distributed. High tissue and urinary levels are achieved. Appears to cross the placenta; enters breast milk.

Metabolism/Excretion: 70–80% excreted unchanged by the kidneys.

Half-life: 5–7 hr.

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POrapid1–2 hr12 hr

Patient/Family Teaching

Pronunciation

oh-FLOX-a-sin