erenumab

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Hypertension;
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Safety and effectiveness not established in children;
Geri: Choose dose carefully in older adults, considering concurrent disease states, drug therapy, and age-related ↓ in hepatic and renal function.

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypertension

GI: constipation

Local: injection site reactions

MS: muscle spasm

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)

Interactions ⬆ ⬇

Drug-drug:

Medications that GI motility may ↑ risk of more severe constipation.

Availability ⬆ ⬇

Solution for injection (prefilled syringes and autoinjectors): 70 mg/mL; 140 mg/mL

Route/Dosage ⬆ ⬇

SC (Adults ): 70 mg once monthly; may ↑ dose, if needed, to 140 mg once monthly.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor, which reduces the neuroinflammatory and vasodilatory effects of CGRP.

Therapeutic effects:

Reduction in frequency of migraines.

Classifications ⬆ ⬇

Therapeutic Classification: vascular headache suppressants

Pharmacologic Classification: monoclonal antibodies, calcitonin gene-related peptide receptor antagonists

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed (82%) following SUBQ administration.

Distribution: Some tissue distribution.

Metabolism/Excretion: Low concentrations: Eliminated through saturable binding to CGRP receptor; High concentrations: Eliminated through nonspecific, nonsaturable proteolytic pathway.

Half-Life: 28 days.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
SUBQ	unknown	6 days	1 mo

Patient/Family Teaching ⬆ ⬇

Instruct patient to take as directed. Administer missed doses as soon as possible and schedule next dose 1 mo from last dose administered. Educate patient and/or caregiver on correct technique for injection and disposal of equipment. Advise patient to read Patient Information before starting therapy and with each Rx refill in case of changes.
Instruct patient to notify health care professional immediately if signs and symptoms of hypersensitivity reaction (swelling of face, mouth, tongue or throat, trouble breathing, rash) occur.
Advise patient to notify health care professional if severe constipation occurs; may cause serious complications.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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Indications ⬇

Contraind./Precautions ⬆ ⬇