Contraindicated in:
Use Cautiously in:
CV: bradycardia, edema, QT interval prolongation, chest pain.
Derm: rash.
EENT: visual disturbances.
Endo: ↓testosterone.
GI: ↑liver enzymes, constipation, diarrhea, nausea, stomatitis, vomiting, ↓ appetite, abdominal pain, esophagitis, HEPATOTOXICITY.
GU: ↓fertility, renal impairment.
Neuro: dysgeusia, fatigue, headache, insomnia, neuropathy.
Resp: INTERSTITIAL LUNG DISEASE (ILD)/PNEUMONITIS.
Misc: fever.
Drug-Drug:
Drug-Natural Products:
Drug-Food:
Non-Small Cell Lung Cancer
Renal Impairment
Hepatic Impairment
Systemic Anaplastic Large Cell Lymphoma
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Inflammatory Myofibroblastic Tumor
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Renal Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Hepatic Impairment
Absorption: 43% absorbed following oral administration.
Distribution: Extensively distributed to tissues.
Metabolism/Excretion: Mostly metabolized by the liver (CYP3A4/5 isoenzymes); also acts as an inhibitor of CYP3A. 53% excreted in feces unchanged, 2.3% eliminated unchanged in urine.
Half-life: 42 hr.