Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

• Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing

Contraindicated in:

• Hypersensitivity or allergy to grape seed extract
• Patients with bleeding disorders or receiving anticoagulant therapy.

Use Cautiously in:

• OB: Avoid use in pregnancy due to lack of safety data.

CV: hypertension.

Derm: dry skin.

EENT: cough, sore throat.

GI: diarrhea, nausea.

Hemat: ↑risk of bleeding.

Neuro: dizziness, headache.

Natural-Drug Products:

• May ↑ anticoagulant effects of warfarin.
• May ↓ plasma levels of CYP1A2 substrates.

Natural-Natural Products:

• May inhibit the growth of lactobacillus acidophilus.
• May ↑ BP in hypertensive patients also taking vitamin c.

• Tablets: ;
• Capsules: ;

• PO (Adults): 75–300 mg daily.

Vitis vinifera, Vitis coignetiae, Oligomeric Proanthocyanidins (OPCs)

• Grape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal, and inhibition of collagenase.

• Reduced risk of coronary disease.
• Decreased skin and vasculature breakdown.

Therapeutic Classification: cardioprotective agents

Absorption: Unknown.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-life: Unknown.

• Advise patient not to take grape seed extract with vitamin C; may cause increase in BP.
• Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected.

grayp seed EX-trakt