mupirocin

REMS

Topical Treatment of:
- Impetigo,
- Secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm² area) caused by Staphylococcus aureus and Streptococcus pyogenes.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity to mupirocin or polyethylene glycol.

Use Cautiously in:

Renal impairment;
Burn patients.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: burning, itching, pain, stinging

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

(Generic available)

Cream: 2%
Ointment: 2%

Route/Dosage ⬆ ⬇

(Adults and Children ≥2 mo): Ointment: Apply 3–5 times daily for 5–14 days.
(Adults and Children ≥3 mo): Cream: Apply small amount 3 times/day for 10 days.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Inhibits bacterial protein synthesis.

Therapeutic effects:

Inhibition of bacterial growth and reproduction.

Spectrum:

Greatest activity against gram-positive organisms, including:
- S. aureus,
- Beta-hemolytic streptococci.
Resolution of impetigo.
Eradication of S. aureus carrier state.

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacokinetics ⬆ ⬇

Absorption: Minimal systemic absorption.

Distribution: Remains in the stratum corneum after topical use for prolonged periods of time (72 hr).

Metabolism/Excretion: Metabolized in the skin, removed by desquamation.

Half-Life: 17–36 min.

Time/Action Profile ⬆ ⬇

(anti-infective effect)

ROUTE	ONSET	PEAK	DURATION
Topical‡	unknown	3–5 days	72 hr

‡Resolution of lesions.

Patient/Family Teaching ⬆ ⬇

Instruct patient on the correct application of mupirocin. Advise patient to apply medication exactly as directed for the full course of therapy. If a dose is missed, apply as soon as possible unless almost time for next dose. Avoid contact with eyes.
Topical Teach patient and family appropriate hygienic measures to prevent spread of impetigo.
- Instruct parents to notify school nurse for screening and prevention of transmission.
- Patient should consult health care professional if symptoms have not improved in 3–5 days.

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Indications ⬇