section name header

Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.

GI: liver enzymes, nausea.

MS: arthralgia, gout flare.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Renal Impairment

US Brand Names

Uloric

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antigout agents

Pharmacologic Classification: xanthine oxidase inhibitors

Pharmacokinetics

Absorption: Well absorbed (49%) following oral administration.

Distribution: Widely distributed to tissues.

Protein Binding: 99.2%.

Metabolism/Excretion: Extensively metabolized by the liver; minimal renal excretion of unchanged drug, 45% eliminated in feces as unchanged drug, remainder is eliminated in urine and feces as inactive metabolites.

Half-life: 5–8 hr.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POrapid1–1.5 hr*24 hr

*Maximum lowering of uric acid may take 2 wk.

Patient/Family Teaching

Pronunciation

fe-BUX-o-stat