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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema.

Derm: STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN).

EENT: blurred vision, nystagmus, vision loss, tunnel vision.

Hemat: anemia.

Metab: weight gain.

MS: arthralgia.

Neuro: abnormal coordination, confusion, drowsiness, fatigue, memory impairment, tremor, INTRAMYELINIC EDEMA, peripheral neuropathy, SUICIDAL THOUGHTS.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Either tablets or powder for oral solution can be used for refractory complex partial seizures; only powder for oral solution should be used for infantile spasms.

Refractory Complex Partial Seizures

Renal Impairment

Infantile Spasms

US Brand Names

Sabril, Vigadrone

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: anticonvulsants

Pharmacokinetics

Absorption: Completely absorbed following oral administration.

Distribution: Enters breast milk, remainder of distribution unknown.

Metabolism/Excretion: Minimal metabolism, mostly eliminated unchanged in urine.

Half-life: 7.5 hr.

Time/Action Profile

(anticonvulsant effect)

ROUTEONSETPEAKDURATION
POunknown1 hr12 hr

†blood level.

†clinical benefit should be seen in 2–4 wk for IS or within 3 mo for complex partial seizures.

Patient/Family Teaching

Pronunciation

vye-GAH-bat-rin