ferric derisomaltose

REMS

Iron deficiency anemia in patients who cannot tolerate/have an unsatisfactory response to oral iron or who have chronic kidney disease (non-dialysis dependent).

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

OB: Severe hypersensitivity reactions may occur which can lead to bradycardia in fetus, especially during second and third trimesters;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Safety and effectiveness not established in children;
Geri: Older adults may be more sensitive to effects.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash

F and E: hypophosphatemia

GI: nausea

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS, SHOCK, AND LOSS OF CONSCIOUSNESS)

Interactions ⬆ ⬇

Drug-drug:

None reported

Availability ⬆ ⬇

Solution for injection: 100 mg/mL

Route/Dosage ⬆ ⬇

IV (Adults ≥50 kg): 1000 mg as single dose; may repeat dose if iron deficiency anemia recurs.
IV (Adults <50 kg): 20 mg/kg (actual body weight) as single dose; may repeat dose if iron deficiency anemia recurs.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

A colloidal iron complex that releases iron into circulation.

Therapeutic effects:

Improvement in hemoglobin concentrations.

Classifications ⬆ ⬇

Therapeutic Classification: antianemics

Pharmacologic Classification: iron supplements

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Iron is rapidly cleared from plasma and used in hemoglobin formation. Small quantities of iron excreted in urine and feces.

Half-Life: 27 hr.

Time/Action Profile ⬆ ⬇

(serum ferritin concentrations)

ROUTE	ONSET	PEAK	DURATION
IV	unknown	7 days	4 wk

Patient/Family Teaching ⬆ ⬇

Explain purpose of medication to patient.
Advise patient to notify health care professional immediately if signs and symptoms of hypersensitivity reactions occur.
Caution patient to notify health care professional promptly if extravasation at IV site occurs.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding. Severe maternal reactions (circulatory failure, severe hypotension, shock, anaphylaxis) may occur increasing risk for preterm delivery and low birth weight. May cause fetal bradycardia, especially in 2nd and 3rd trimester. Monitor breastfed infants for GI toxicity (constipation, diarrhea).

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Indications ⬇