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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

GI: diarrhea, nausea, vomiting.
Misc: hypersensitivity reactions.

Interactions

Interactions are listed for systemically absorbed drug

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

Preoperative Intestinal Antisepsis

Hepatic Encephalopathy

Action

Therapeutic Effects:

Spectrum:

Classifications

Therapeutic Classification: anti-infectives

Pharmacologic Classification: aminoglycosides

Pharmacokinetics

Absorption: Minimal systemic absorption, but may accumulate in patients with renal failure.

Distribution: Widely distributed throughout extracellular fluid; crosses the placenta; small amounts enter breast milk. Poor penetration into CSF.

Metabolism/Excretion: Excretion is >90% renal.

Half-life: 2–4 hr (increased in renal impairment).

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POrapid1–4 hrN/A

Patient/Family Teaching

Pronunciation

nee-oh-MYE-sin