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Indications

High Alert

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Incidence and severity of adverse reactions and side effects are increased with IV use

CV: PO: CARDIAC TAMPONADE (WITH HIGH-DOSE CYCLOPHOSPHAMIDE).
IV: chest pain, hypotension, tachycardia, thrombosis, arrhythmias, atrial fibrillation, cardiomegaly, ECG changes, edema, heart block, HF, hypertension, pericardial effusion, ventricular extrasystoles.

Derm: PO: itching, rash, acne, alopecia, erythema nodosum, exfoliative dermatitis, hyperpigmentation.

EENT: PO: cataracts.
IV: epistaxis, pharyngitis, ear disorders.

Endo: PO and IV: hyperuricemia.
IV: hyperglycemia.
PO: sterility, gynecomastia.

F and E: hypokalemia, hypomagnesemia, hypophosphatemia.

GI: PO: drug-induced hepatitis, nausea, vomiting.
IV: abdominal enlargement, anorexia, constipation, diarrhea, dry mouth, hematemesis, nausea, rectal discomfort, vomiting, abdominal pain, dyspepsia, hepatic veno-occlusive disease ( in allogenic transplantation), hepatomegaly, pancreatitis, stomatitis.

GU: oliguria, dysuria, hematuria, fertility.

Hemat: BONE MARROW DEPRESSION.

Local: inflammation/pain at injection site.

MS: arthralgia, myalgia, back pain.

Neuro: IV: anxiety, confusion, depression, dizziness, headache, weakness., CEREBRAL HEMORRHAGE/COMA, encephalopathy, mental status changes, SEIZURES.

Resp: PO: PULMONARY FIBROSIS.
IV: alveolar hemorrhage, asthma, atelectasis, cough, hemoptysis, hypoxia, pleural effusion, pneumonia, rhinitis, sinusitis.
Misc: allergic reactions, chills, fever, infection.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

US Brand Names

Busulfex, Myleran

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: alkylating agents

Pharmacokinetics

Absorption: Rapidly absorbed from the GI tract following oral administration. IV administration results in complete bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Extensively metabolized by the liver.

Half-life: 2.5 hr.

Time/Action Profile

(effect on blood counts)

ROUTEONSETPEAKDURATION
PO1–2 wkweeksup to 1 mo
IVunknownunknown13 days

†Complete recovery may take up to 20 mo.

†After administration of last dose.

Patient/Family Teaching

Pronunciation

byoo-SUL-fan