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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: rash.

F and E: hypophosphatemia.

GI: diarrhea, nausea, abdominal pain, anorexia, flatulence, LACTIC ACIDOSIS/HEPATOMEGALY WITH STEATOSIS, vomiting.

GU: ACUTE RENAL FAILURE/FANCONI SYNDROME, proximal renal tubulopathy, renal impairment.

MS: bone mineral density, bone pain, muscle pain, osteomalacia.

Neuro: depression, headache, weakness.
Misc: immune reconstitution syndrome.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Renal Impairment

US Brand Names

Viread

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: nucleoside reverse transcriptase inhibitors

Pharmacokinetics

Absorption: Tenofovir disoproxil fumarate is a prodrug, which is split into tenofovir, the active component. Absorption enhanced by food.

Distribution: Minimally distributed to extravascular tissues.

Metabolism/Excretion: 70–80% excreted unchanged in urine by glomerular filtration and active tubular secretion.

Half-life: Unknown.

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POunknown2 hr*24 hr

*When taken with food.

Patient/Family Teaching

Pronunciation

te-NOE-fo-veer dye-soe-PROX-il FUE-ma-rate