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Indications

High Alert

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: cardiomyopathy, hypertension.

Derm: alopecia, erythema, photosensitivity, rash.

EENT: retinopathy.

F and E: hyperkalemia, hypocalcemia, hypokalemia, hyponatremia, hypophosphatemia.

GI: diarrhea, hypoalbuminemia, nausea, stomatitis, vomiting, HEPATOTOXICITY.

GU: serum creatinine, fertility.

Hemat: anemia, hemorrhage, lymphopenia, thrombocytopenia.

MS: creatine kinase, RHABDOMYOLYSIS.
Misc: fever, MALIGNANCY.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

Route/Dosage

US Brand Names

Cotellic

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: kinase inhibitors

Pharmacokinetics

Absorption: 46% absorbed following oral administration.

Distribution: Extensively distributed to tissues.

Protein Binding: 95%.

Metabolism/Excretion: Mostly metabolized by the liver (via CYP3A4 enzyme system and glucuronidation). 6.6% excreted in feces unchanged; 20% excreted in urine (mostly as metabolites).

Half-life: 44 hr.

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POunknown2.4 hrunknown

Patient/Family Teaching

Pronunciation

koe-bi-ME-ti-nib