SC (Adults and Children ≥20 kg): 3 mg/kg once monthly for 3 doses (loading dose), followed by 3 mg/kg every 3 mo (maintenance dose).
SC (Adults and Children 10–<20 kg): 6 mg/kg once monthly for 3 doses (loading dose), followed by 6 mg/kg every 3 mo (maintenance dose).
SC (Adults and Children <10 kg): 6 mg/kg once monthly for 3 doses (loading dose), followed by 3 mg/kg once monthly (maintenance dose).
US Brand Names⬆⬇
Oxlumo
Action⬆⬇
Reduces levels of glycolate oxidase enzyme by targeting the hydroxyacid oxidase 1 messenger ribonucleic acid in hepatocytes through RNA interference, which leads to a reduction in production of oxalate.
Therapeutic effects:
Reduction in urinary and plasma oxalate levels.
Classifications⬆⬇
Therapeutic Classification: none assigned
Pharmacologic Classification:
Pharmacokinetics⬆⬇
Absorption: Rapidly absorbed following SUBQ administration.
Distribution: Minimally distributed to extravascular tissues.
Metabolism/Excretion: Metabolized by endonucleases and exonucleases to oligonucleotides of shorter length. Primarily excreted in urine as inactive metabolites (74%), with <26% excreted unchanged in urine.
Half-Life: 5.2 hr.
Time/Action Profile⬆⬇
(↓ in oxalate levels)
ROUTE
ONSET
PEAK
DURATION
SUBQ
days
2–3 mo
unknown
Patient/Family Teaching⬆⬇
Explain purpose and side effects of lumasiran to patient. Do not stop receiving drug without consulting health care professional. If an appointment is missed, contact health care professional as soon as possible to reschedule. Advise patient to read Medication Guide before starting and periodically during therapy in case of changes.
Explain need for continued medical follow-up to assess effectiveness and possible side effects of medication. Periodic lab tests will be needed.
Inform patient that side effects may include injection site reactions and abdominal pain.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Rep: Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
