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Indications

High Alert


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Availability

Route/Dosage

When switching from immediate-release to extended-release product, the same total daily dose can be used.

Hepatic Impairment

US Brand Names

Nucynta, Nucynta ER

Action

  • Acts as a mu-opioid receptor agonist.
  • Also inhibits the reuptake of norepinephrine.
Therapeutic effects:
  • Decrease in pain severity.

Classifications

Therapeutic Classification: analgesics (centrally acting), opioid analgesics

Pharmacologic Classification: opioid agonists

Pharmacokinetics

Absorption: 32% absorbed following oral administration.

Distribution: Widely distributed.

Metabolism/Excretion: Undergoes extensive first-pass hepatic metabolism (97%); metabolites have no analgesic activity; metabolized drug is 99% renally excreted.

Half-Life: 4 hr.

Contr. Subst. Schedule

Schedule II (C-II)

Canadian Brand Names

Nucynta IR

Time/Action Profile

(analgesic effect)

ROUTEONSETPEAKDURATION
POunknown1 hr4–6 hr



Patient/Family Teaching

Pronunciation

ta-PEN-ta-dol