miconazole (Oral)

Contraindicated in:

Hypersensitivity to miconazole or other components of formulation (including milk protein)
Systemic candidiasis
OB: Pregnancy.

Use Cautiously in:

Hepatic impairment
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant
Pedi: Safety and effectiveness in children not established.

Adv. Reactions/Side Effects ⬆ ⬇

GI: abnormal mouth sensations, diarrhea, dry mouth, dysgeusia, ↑ liver function tests, nausea, vomiting.

Derm: pruritis.

Neuro: headache.
Misc: ANAPHYLAXIS.

Interactions ⬆ ⬇

Drug-Drug:

May ↓ metabolism and ↑ risk of toxicity from CYP3A4 substrates, including cyclosporine, HMG-CoA reductase inhibitors, some benzodiazepines (alprazolam, midazolam, triazolam), calcium channel blockers, colchicine, fentanyl, sulfonylureas (glipizide, glyburide), phenytoin, tacrolimus, and warfarin.

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Affects the permeability of the fungal cell wall, allowing leakage of cellular contents.

Therapeutic Effects:

Classifications ⬆ ⬇

Therapeutic Classification: antifungals (oral, nonabsorbed)

Pharmacokinetics ⬆ ⬇

Absorption: Minimal systemic absorption.

Distribution: Inhibitory concentrations remain in saliva for up to 7 hr after buccal application of tablet.

Metabolism/Excretion: .

Half-life: .

Time/Action Profile ⬆ ⬇

ROUTE	ONSET	PEAK	DURATION
PO	unknown	unknown	up to 15 hr

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Instruct patient to take as directed. Describe application and what to do if tablet falls off or is swallowed.
Advise patient of allergic and hypersensitivity reactions. If they occur, notify a health care professional immediately and seek emergent medical attention if needed.
Advise patient to notify a health care professional of milk allergies before starting treatment.
May cause fetal harm. Advise pregnant women of the potential risks to a fetus. Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.