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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Availability

(Generic available)

Route/Dosage

US Brand Names

Nallpen

Action

  • Bind to bacterial cell wall, leading to cell death. Not inactivated by penicillinase enzymes.
Therapeutic effects:
  • Bactericidal action.

Spectrum:

Classifications

Therapeutic Classification: anti-infectives

Pharmacologic Classification: penicillinase resistant penicillins

Pharmacokinetics

Absorption: Completely absorbed following IV administration; well absorbed from IM sites.

Distribution: Widely distributed; penetration into CSF is minimal but sufficient in the presence of inflamed meninges; cross the placenta and enter breast milk.

Protein Binding: 90% to albumin.

Metabolism/Excretion: Partially metabolized by the liver (60%), partially excreted unchanged by the kidneys.

Half-Life: Neonates: 1–5 hr; Children 1 mo – 14 yr: 0.75–1.9 hr; Adults: 0.5–1.5 hr (increased in renal impairment).

Time/Action Profile

ROUTEONSETPEAKDURATION
Nafcillin IM30 min60–120 min4–6 hr
Nafcillin IVrapidend of infusion4–6 hr



Patient/Family Teaching

Pronunciation

naf-SILL-in