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Indications

REMS

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Adverse reactions/side effects are much more common with high-dose/long-term therapy

CV: hypertension.

Derm: wound healing, acne, ecchymoses, fragility, hirsutism, petechiae.

EENT: intraocular pressure, cataracts.

Endo: adrenal suppression, hyperglycemia.

F and E: fluid retention (long-term high doses), hypokalemia, hypokalemic alkalosis.

GI: anorexia, nausea, PEPTIC ULCERATION, vomiting.

Hemat: THROMBOEMBOLISM, thrombophlebitis.

Metab: weight gain, weight loss.

MS: muscle wasting, osteoporosis, avascular necrosis of joints, muscle pain.

Neuro: depression, euphoria, intracranial pressure (children only), headache, personality changes, psychoses, restlessness.
Misc: cushingoid appearance (moon face, buffalo hump), susceptibility to infection, (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS .

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

US Brand Names

Celestone Soluspan

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: corticosteroids

Pharmacologic Classification: corticosteroids

Pharmacokinetics

Absorption: Sodium phosphate salt is rapidly absorbed after IM administration. Acetate salt is slowly but completely absorbed after IM administration. Absorption from local sites (intra-articular, intralesional) is slow but complete.

Distribution: Widely distributed; crosses the placenta and probably enters breast milk.

Metabolism/Excretion: Metabolized mostly by the liver.

Half-life: 3–5 hr (plasma), 36–54 hr (tissue); adrenal suppression lasts 3.25 days.

Canadian Brand Names

Betaject

Time/Action Profile

(anti-inflammatory activity)

ROUTEONSETPEAKDURATION
IM (sodium phosphate/acetate)1–3 hrunknown1 wk

Patient/Family Teaching

Pronunciation

bay-ta-METH-a-sone