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Indications

BEERS REMS

OTC:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: chest pain.

Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, cutaneous lupus erythematosus, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), itching, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.

F and E: hypocalcemia (especially if treatment duration ge.gif3 mo), hypokalemia (especially if treatment duration ge.gif3 mo), hypomagnesemia (especially if treatment duration ge.gif3 mo).

GI: abdominal pain, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), constipation, diarrhea, flatulence, fundic gland polyps, nausea, vomiting.

GU: acute tubulointerstitial nephritis.

MS: bone fracture.

Neuro: dizziness, drowsiness, fatigue, headache, weakness.
Misc: (INCLUDING ANAPHYLAXIS, ANGIOEDEMA, OR TUBULOINTERSTITIAL NEPHRITIS)HYPERSENSITIVITY REACTIONS , systemic lupus erythematosus, vitamin B12 deficiency.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

US Brand Names

PriLOSEC, PriLOSEC OTC

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antiulcer agents

Pharmacologic Classification: proton pump inhibitors

Pharmacokinetics

Absorption: Rapidly absorbed following oral administration; immediate release formulation contains bicarbonate to prevent acid degradation.

Distribution: Good distribution into gastric parietal cells.

Protein Binding: 95%.

Metabolism/Excretion: Mostly metabolized by the liver via the CYP2C19 isoenzyme, and to a lesser extent by the CYP3A4 isoenzyme; the CYP2C19 isoenzyme exhibits genetic polymorphism (15–20% of Asian patients and 3–5% of Caucasian and Black patients may be poor metabolizers and may have significantly omeprazole concentrations and an risk of adverse effects); inactive metabolites are excreted in urine (77%) and feces.

Half-life: 0.5–1 hr ( in liver disease to 3 hr).

Canadian Brand Names

Losec

Time/Action Profile

(antisecretory effects)

ROUTEONSETPEAKDURATION
PO-delayed releasewithin 1 hrwithin 2 hr72–96 hr

Patient/Family Teaching

Pronunciation

o-MEP-ra-zole

Pill Image

omeprazole_rx_195_8644.jpg