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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Exercise Extreme Caution in:

Adv. Reactions/Side Effects

CV: CORONARY ARTERY VASOSPASM, MI, myocardial ischemia, VENTRICULAR FIBRILLATION, VENTRICULAR TACHYCARDIA.

GI: nausea.

Neuro: dizziness, drowsiness, fatigue, paresthesia.
Misc: pain/pressure sensation in throat/neck.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

US Brand Names

Amerge

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: vascular headache suppressants

Pharmacologic Classification: five ht1 agonists

Pharmacokinetics

Absorption: Well absorbed (70%) following oral administration.

Distribution: Extensively distributed to tissues.

Metabolism/Excretion: Primarily metabolized in the liver. 60% excreted unchanged in urine; 30% metabolized by the liver.

Half-life: 6 hr ( in renal impairment).

Time/Action Profile

( migraine pain)

ROUTEONSETPEAKDURATION
PO30–60 min2–3 hrup to 24 hr

†3–4 hr during migraine attack.

Patient/Family Teaching

Pronunciation

nar-a-TRIP-tan