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Indications

REMS

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

For parenteral form, unless otherwise indicated

EENT: inhalation: burning in throat.

Neuro: anxiety, headache, confusion, dizziness, hallucinations.

Resp: inhalation: bronchospasm, cough.

CV: ARRHYTHMIAS, hypotension, chest pain.

GI: PANCREATITIS, abdominal pain, anorexia, drug-induced hepatitis, nausea, unpleasant metallic taste, vomiting.

GU: nephrotoxicity.

Derm: pallor, rash.

Endo: hypoglycemia, hyperglycemia.

F and E: hyperkalemia, hypocalcemia.

Hemat: anemia, leukopenia, thrombocytopenia.

Local: IV: phlebitis, pruritus, urticaria at IV site.
IM: sterile abscesses at IM sites.
Misc: ALLERGIC REACTIONS INCLUDING ANAPHYLAXIS, STEVENS-JOHNSON SYNDROME, chills, fever.

Interactions

Interactions listed for parenteral administration

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

Renal Impairment

US Brand Names

NebuPent, Pentam 300

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: anti-infectives

Pharmacokinetics

Absorption: Well absorbed parenterally; Minimal systemic absorption occurs following inhalation.

Distribution: Widely and extensively distributed but does not cross the blood-brain barrier. Concentrates in liver, kidneys, lungs, and spleen, with prolonged storage in some tissues.

Metabolism/Excretion: 1–30% excreted unchanged by the kidneys. Remainder of metabolic fate unknown.

Half-life: 5–11 hr ( in renal impairment).

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
IVunknownend of infusion24 hr
Inhalnunknownunknownunknown

Patient/Family Teaching

Pronunciation

pen-TAM-i-deen