• Severe hypoglycemia in patients with diabetes.

Contraindicated in:

• Pheochromocytoma
• Insulinoma.

Use Cautiously in:

• Starvation, adrenal insufficiency, or chronic hypoglycemia (may be ineffective; use glucose)
• Pedi: Children <6 yr (safety and effectiveness not established).

CV: bradycardia, hypertension, hypotension, palpitations, presyncope.

GI: nausea, vomiting, diarrhea.

Local: injection site pain.

Neuro: headache.
Misc: (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS .

Drug-Drug:

• Use with beta blockers may cause transient ↑ in HR and BP.
• Indomethacinmay ↓ effectiveness and may even lead to hypoglycemia.
• May ↑ effects and risk of bleeding with warfarin.

• Solution for injection (prefilled syringes and autoinjectors): 0.6 mg/0.6 mL;

• SC (Adults and Children 6 yr): 0.6 mg initially; may repeat in 15 min if no response using a new device.

Zegalogue

• Stimulates glucagon receptors in liver, which stimulates the breakdown of glycogen and release of glucose from the liver.

• Increase in blood glucose.

Therapeutic Classification: hormones

Pharmacologic Classification: pancreatics

Absorption: Unknown.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Excreted through proteolytic degradation pathways in blood, liver, and kidney.

Half-life: 30 min.

(increase in blood glucose concentrations)

• Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy.
• Teach patient about recognition of hypoglycemia and risks of prolonged hypoglycemia. Educate family, friends, and caregivers regarding these signs and on how to administer dasiglucagon and where it is kept. After each administration, a health care professional must be immediately contacted.
• Advise patient that once food or drink may be consumed safely, fast-acting (juice) and long-acting (crackers with cheese) sources of sugar should be given.
• Explain signs and symptoms of hypersensitivity reactions to patient and advise them to immediately seek medical care if difficulty breathing or significant dizziness occur.
• Instruct patient to check expiration date monthly and to replace outdated medication immediately.
• Review reasons for carrying sources of sugar, medical identification, and treatment regimen at all times with patients with diabetes mellitus.
• Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
• Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

DAS-i-GLOO-ka-gon