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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: acneiform eruptions, allergic dermatitis.

EENT: optic neuritis.

GI: HEPATOTOXICITY, metallic/garlic-like taste.

GU: erectile dysfunction.

Neuro: drowsiness, fatigue, headache, peripheral neuritis/neuropathy, polyneuritis, psychoses.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

US Brand Names

Antabuse

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: alcohol abuse therapy adjuncts

Pharmacologic Classification: enzyme inhibitors

Pharmacokinetics

Absorption: Slowly absorbed from the GI tract.

Distribution: Unknown.

Metabolism/Excretion: Rapidly and extensively metabolized; some hepatic metabolism. Metabolites a slowly eliminated by the kidneys.

Half-life: Unknown.

Time/Action Profile

ROUTEONSETPEAKDURATION
POslow8–10 hr24 hr

Patient/Family Teaching

Pronunciation

di-SUL-fir-am