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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: alopecia, rash, urticaria.

EENT: blurred vision.

GI: abdominal pain, diarrhea, epigastric pain, flatulence, gallstones, heartburn, nausea, vomiting.

Hemat: anemia, leukopenia.

MS: myositis.

Neuro: dizziness, headache.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

US Brand Names

Lopid

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: fibric acid derivatives

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Unknown.

Metabolism/Excretion: Some metabolism by the liver, 70% excreted by the kidneys (mostly unchanged), 6% excreted in feces.

Half-life: 1.3–1.5 hr.

Time/Action Profile

(triglyceride-lowering effect)

ROUTEONSETPEAKDURATION
PO2–5 days4 wkseveral mo

Patient/Family Teaching

Pronunciation

gem-FYE-broe-zil