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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: pruritus.

GI: diarrhea, HBV reactivation, hyperbilirubinemia, nausea.

Neuro: fatigue, headache.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

Route/Dosage

US Brand Names

Mavyret

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antivirals

Pharmacologic Classification: NS5A inhibitors, protease inhibitors

Pharmacokinetics

Glecaprevir

Absorption: Well absorbed following oral administration; absorption by high-fat meal.

Distribution: Unknown.

Protein Binding: 97.5%.

Metabolism/Excretion: Partially metabolized by the liver via the CYP3A4 isoenzyme; 92% excreted in feces and <1% eliminated in urine.

Half-life: 6 hr.

Pibrentasvir

Absorption: Well absorbed following oral administration.

Distribution: Unknown.

Protein Binding: >99.9%.

Metabolism/Excretion: Not metabolized; 97% excreted in feces.

Half-life: 13 hr.

Canadian Brand Names

Maviret

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
glecaprevir (PO)unknown5 hr24 hr
pibrentasvir (PO)unknown5 hr24 hr

Patient/Family Teaching

Pronunciation

glek-A-pre-vir/pi-BRENT-as-vir