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Indications

BEERS REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: photosensitivity, rash.

Endo: hypoglycemia.

F and E: hyponatremia.

GI: constipation, cramps, diarrhea, dyspepsia, hepatitis, nausea, vomiting.

Hemat: agranulocytosis, APLASTIC ANEMIA, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia.

Metab: appetite.

Neuro: dizziness, drowsiness, headache, weakness.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

US Brand Names

Glucotrol, Glucotrol XL

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antidiabetics

Pharmacologic Classification: sulfonylureas

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Unknown.

Protein Binding: 99%.

Metabolism/Excretion: Mostly metabolized by the liver.

Half-life: 2.1–2.6 hr.

Time/Action Profile

(hypoglycemic activity)

ROUTEONSETPEAKDURATION
PO15–30 min1–2 hrup to 24 hr

Patient/Family Teaching

Pronunciation

GLIP-i-zide