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Indications

High Alert

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension.

Endo: adrenal insufficiency.

GI: diarrhea, nausea, vomiting.

GU: fertility.

Neuro: allodynia, dizziness, headache, hyperalgesia, SEIZURES, somnolence.

Resp: RESPIRATORY DEPRESSION (INCLUDING CENTRAL SLEEP APNEA AND SLEEP-RELATED HYPOXEMIA).
Misc: (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)HYPERSENSITIVITY REACTIONS .

Interactions

Drug-Drug:

Availability

Route/Dosage

When switching from immediate-release to extended-release product, the same total daily dose can be used.

Hepatic Impairment

US Brand Names

Nucynta, Nucynta ER

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: analgesics (centrally acting), opioid analgesics

Pharmacologic Classification: opioid agonists

Pharmacokinetics

Absorption: 32% absorbed following oral administration.

Distribution: Widely distributed.

Metabolism/Excretion: Undergoes extensive first-pass hepatic metabolism (97%); metabolites have no analgesic activity; metabolized drug is 99% renally excreted.

Half-life: 4 hr.

Contr. Subst. Schedule

Schedule II (C-II)

Canadian Brand Names

Nucynta IR

Time/Action Profile

(analgesic effect)

ROUTEONSETPEAKDURATION
POunknown1 hr4–6 hr

Patient/Family Teaching

Pronunciation

ta-PEN-ta-dol