• Prostate cancer (in combination with a luteinizing hormone-releasing hormone [LHRH] agonist).

Contraindicated in:

• Hypersensitivity
• Severe hepatic impairment.

Use Cautiously in:

• Severe cardiovascular disease.

Side effects primarily caused by LHRH antagonist

CV: edema, hypertension.

Derm: photosensitivity, rash.

Endo: gynecomastia, hot flushes.

GI: diarrhea, nausea, vomiting, HEPATOTOXICITY.

GU: erectile dysfunction, loss of libido.

Neuro: anxiety, confusion, drowsiness, mental depression, nervousness.

Drug-Drug:

• Acts synergistically with LHRH analogues (leuprolide).

(Generic available)

• Capsules: 125 mg; 250 mg;

• PO (Adults): 250 mg every 8 hr.

Eulexin

• Antagonizes the effects of androgen (testosterone) at the cellular level.

• Decreased growth of prostate carcinoma, an androgen-sensitive tumor.

Therapeutic Classification: antineoplastics

Pharmacologic Classification: antiandrogens

Absorption: Well absorbed after oral administration.

Distribution: Unknown.

Metabolism/Excretion: Mostly metabolized by the liver. Some conversion to another antiandrogenic compound (2-hydroxyflutamide).

Half-life: Unknown.

• Explain that flutamide must be taken in conjunction with leuprolide. Instruct patient to take flutamide exactly as directed. If a dose is missed, take as soon as possible unless almost time for next dose. Do not double doses.
• Warn patient that side effects such as hot flashes, loss of sex drive, erectile dysfunction, and breast enlargement may be caused by the LHRH agonist. The primary side effect of flutamide alone is diarrhea, but the combination of drugs is necessary to achieve the therapeutic effect.
• Advise patient to notify health care professional immediately if dark urine, itching, loss of appetite, nausea, vomiting, pain in right side, or yellow eyes or skin occurs. Hepatotoxicity usually resolves when flutamide is discontinued, but it may be progressive and fatal; requires immediate medical attention.

FLOO-ta-mide