denileukin diftitox

Contraindicated in:

OB: Pregnancy;
Lactation: Lactation.

Use Cautiously in:

Rep: Women of reproductive potential;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

CV: capillary leak syndrome, edema

Derm: pruritus, rash, skin infection

EENT: blurred vision, loss of color vision

GI: ↑liver enzymes, constipation, diarrhea, HEPATOTOXICITY, nausea, vomiting

GU: ↓fertility (males), renal impairment

Hemat: anemia, lymphopenia

Metab: ↓appetite, hypoalbuminemia, weight gain

MS: ↑creatinine kinase, arthralgia, myalgia

Neuro: dizziness, fatigue, headache, insomnia, mental status changes

Misc: chills, fever, infusion-related reactions

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

Lyophilized powder for injection: 300 mcg/vial

Route/Dosage ⬆ ⬇

IV (Adults ): 9 mcg/kg/day for 5 consecutive days every 21 days; continue until disease progression or unacceptable toxicity.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

A fusion protein that contains parts of diphtheria toxin fused to interleukin (IL)-2. Directs cytocidal action of diphtheria toxin to cells/tumors with IL-2 receptors.

Therapeutic effects:

Regression of cutaneous T-cell lymphoma.

Classifications ⬆ ⬇

Therapeutic Classification: antineoplastics

Pharmacologic Classification: cytotoxic proteins

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Not extensively distributed to tissues.

Metabolism/Excretion: Metabolized by proteolytic breakdown.

Half-Life: 70–80 min.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
IV	unknown	end of infusion	unknown

Patient/Family Teaching ⬆ ⬇

Advise patient to perform daily weights and notify health care professional immediately if capillary leak syndrome (edema, ↑ BP, weight gain) occur.
Advise patient to notify health care professional promptly of visual changes, infusion reaction symptoms, easy bruising or bleeding, or signs of hepatotoxicity (fatigue, anorexia, jaundice, dark urine, right abdominal pain).
Caution patient to avoid crowds and use soft toothbrush and electric razor. Caution patient not to drink alcoholic beverages or take products containing aspirin or NSAIDs.
Rep: May cause fetal harm. Advise women of reproductive potential to use effective contraception during treatment and for 7 days following the last dose and to not breastfeed during therapy.

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Indications ⬇

Contraind./Precautions ⬆ ⬇