Atracurium
- IV (Adults and Children >2 yr): 0.4–0.5 mg/kg initially (0.25–0.35 mg/kg if administered after steady-state anesthesia with enflurane or isoflurane or 0.3–0.4 mg/kg following succinylcholine); may then repeat with 0.08–0.1 mg/kg 20–45 min after initial dose as needed, or by continuous infusion at 5–9 mcg/kg/min.
- IV (Neonates , Infants, and Children 1 mo–2 yr): 0.3–0.4 mg/kg initially followed by maintenance doses of 0.3–0.4 mg/kg as needed.
Cisatracurium
- IV (Adults and Children >12 yr): Initial intubating dose—0.15–0.2 mg/kg, additional maintenance doses of 0.03 mg/kg may be used 40–65 min later; Continuous infusion—1–3 mcg/kg/min.
- IV (Children 2–12 yr): Initial intubating dose—0.1–0.15 mg/kg; Continuous infusion—1–3 mcg/kg/min.
- IV (Infants 1–23 mo): Initial intubating dose—0.15 mg/kg.
Pancuronium
- IV (Adults and Children >1 mo): Initial intubating dose—0.06–0.1 mg/kg initially; additional doses of 0.01 mg/kg may be given every 25–60 min to maintain paralysis. Continuous infusion—1–2 mcg/kg/min.
Rocuronium
- IV (Adults ): Rapid sequence tracheal intubation—0.6–1.2 mg/kg; Maintenance dosing—0.1–0.2 mg/kg, repeat doses as needed; Continuous infusion—10–12 mcg/kg/min (range 4–16 mcg/kg/min).
- IV (Children ≥3 mo): Intubation dose—0.6 mg/kg; Maintenance dose— 0.075–0.125 mg/kg; Continuous infusion—12 mcg/kg/min.
Vecuronium
- IV (Adults and Children >10 yr): Intubation—0.08–0.1 mg/kg (0.06–0.085 mg/kg if given after steady-state anesthesia achieved or 0.04–0.06 mg/kg after succinylcholine-assisted intubation and anesthesia; wait for disappearance of succinylcholine effects; or 0.05–0.06 mg/kg during balanced anesthesia); Maintenance dose—0.01–0.015 mg/kg 25–40 min after initial dose, then every 12–15 min as needed; Continuous infusion— 0.8–1.2 mcg/kg/min.
- IV (Children 1–10 yr): 0.1 mg/kg every 1 hr as needed.
- IV (Infants 7 wk– 1 yr): 0.1 mg/kg every 1 hr as needed or as a continuous infusion of 1–1.5 mcg/kg/min.