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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Exercise Extreme Caution in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Availability

(Generic available)

Route/Dosage

Osteoarthritis

Hepatic Impairment

Rheumatoid Arthritis

Hepatic Impairment

Ankylosing Spondylitis

Hepatic Impairment

Juvenile Rheumatoid Arthritis

Hepatic Impairment

Acute Pain or Primary Dysmenorrhea

Hepatic Impairment

Acute Treatment of Migraine

Hepatic Impairment

US Brand Names

CeleBREX, Elyxyb

Action

  • Inhibits the enzyme COX-2. This enzyme is required for the synthesis of prostaglandins.
  • Has analgesic, anti-inflammatory, and antipyretic properties.
Therapeutic effects:
  • Decreased pain and inflammation caused by osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, or juvenile rheumatoid arthritis.
  • Decreased acute pain.

Classifications

Therapeutic Classification: antirheumatics

Pharmacologic Classification: cox 2 inhibitors

Pharmacokinetics

Absorption: Bioavailability unknown.

Distribution: Extensively distributed to tissues.

Protein Binding: 97%.

Metabolism/Excretion: Mostly metabolized by the liver via the CYP2C9 isoenzyme; the CYP2C9 isoenzyme exhibits genetic polymorphism; poor metabolizers may have significantly celecoxib concentrations and an risk of adverse effects; <3% excreted unchanged in urine and feces.

Half-Life: 11 hr.

Time/Action Profile

(pain reduction)

ROUTEONSETPEAKDURATION
PO24–48 hrunknown12–24 hr

After discontinuation.



Patient/Family Teaching

Pronunciation

sel-e-KOX-ib

Pill Image

celecoxib_195-8706.jpg