lusutrombopag

REMS

Treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Lactation: Lactation.

Use Cautiously in:

Risk factors for thromboembolism (Factor V Leiden, Prothrombin 20210A, Antithrombin deficiency, Protein C or S deficiency);
OB: Safety not established in pregnancy;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

CV: THROMBOEMBOLISM

GI: PORTAL VEIN THROMBOSIS

Neuro: headache

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

Should not be used in patients with chronic liver disease to normalize platelet counts.
PO (Adults ): 3 mg once daily for 7 days. Begin therapy 8–14 days prior to the scheduled procedure such that the procedure takes place 2–8 days after the final dose.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Acts as a thrombopoietin receptor agonist which increases platelet production by initiating proliferation and differentiation of megakaryocytes from bone marrow progenitor cells.

Therapeutic effects:

Reduction in need for platelet transfusions prior to procedure.
Reduction in need fore rescue therapy for bleeding after procedure.
Increased platelet count.

Classifications ⬆ ⬇

Therapeutic Classification: antithrombocytopenics

Pharmacologic Classification: thrombopoietin receptor agonists

Pharmacokinetics ⬆ ⬇

Absorption: Unknown.

Distribution: Well distributed to tissues.

Protein Binding: >99%.

Metabolism/Excretion: Primarily metabolized in liver via CYP4 isoenzymes. Primarily excreted in feces (83%) with 16% being eliminated as unchanged drug.

Half-Life: 27 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	6–8 hr	24 hr

Patient/Family Teaching ⬆ ⬇

Instruct patient to take medication as directed. Take missed doses as soon as remembered on same day and return to scheduled dose next day. Advise patient to read Patient Information before starting therapy.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected and to avoid breastfeeding during and for at least 28 days after last dose.

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Indications ⬇