section name header

Indications

BEERS REMS

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema, hypotension.

Derm: BULLOUS DERMATITIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), ERYTHEMA MULTIFORME, pruritus, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.

EENT: sinusitis.

Endo: SIADH.

F and E: thirst, hyponatremia.

GI: appetite, constipation, dry mouth, liver enzymes, abdominal pain, anorexia, nausea, vomiting.

GU: urinary frequency.

Hemat: AGRANULOCYTOSIS.

Metab: weight gain, hypercholesterolemia, hypertriglyceridemia.

MS: arthralgia, back pain, myalgia.

Neuro: drowsiness, abnormal dreams, abnormal thinking, agitation, akathisia, anxiety, apathy, confusion, dizziness, hyperkinesia, hypoesthesia, malaise, NEUROLEPTIC MALIGNANT SYNDROME, SUICIDAL THOUGHTS, twitching, weakness.

Resp: cough, dyspnea.
Misc: flu-like syndrome, SEROTONIN SYNDROME.

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

US Brand Names

Remeron, Remeron SolTab

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antidepressants

Pharmacologic Classification: tetracyclic antidepressants

Pharmacokinetics

Absorption: Well absorbed but rapidly metabolized, resulting in 50% bioavailability.

Distribution: Unknown.

Protein Binding: 85%.

Metabolism/Excretion: Extensively metabolized by the liver by the CYP1A2, CYP2D6, and CYP3A isoenzymes; metabolites excreted in urine (75%) and feces (15%).

Half-life: 20–40 hr.

Canadian Brand Names

Remeron RD

Time/Action Profile

(antidepressant effect)

ROUTEONSETPEAKDURATION
PO1–2 wk6 wk or moreunknown

Patient/Family Teaching

Pronunciation

meer-TAZ-a-peen