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Indications

BEERS REMS

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Exercise Extreme Caution in:

Adv. Reactions/Side Effects

Derm: acne, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria.

EENT: abnormal vision, diplopia, nystagmus.

Endo: SIADH, hypothyroidism.

F and E: thirst, hyponatremia.

GI: abdominal pain, nausea, vomiting, dyspepsia.

Hemat: lymphadenopathy.

Neuro: ataxia, dizziness, drowsiness, gait disturbances, headache, tremor, vertigo, cognitive symptoms, SEIZURES, SUICIDAL THOUGHTS.
Misc: hypersensitivity reactions.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

see Calculator

(Immediate-release tablets and oral suspension can be interchanged at equal doses.)

Renal Impairment

US Brand Names

Oxtellar XR, Trileptal

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: anticonvulsants

Pharmacologic Classification: carbamazepine analogues

Pharmacokinetics

Absorption: Rapidly absorbed after oral administration and rapidly converted to the active 10-hydroxy metabolite (MHD).

Distribution: Extensively distributed to tissues.

Metabolism/Excretion: Extensively converted to the active metabolite, MHD, which is then primarily excreted by the kidneys.

Half-life: Oxcarbazepine: 2 hr; MHD: 9 hr.

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POPOrapid4.5 hr

†Steady-state levels of MHD are reached after 2–3 days during twice-daily dosing.

Patient/Family Teaching

Pronunciation

ox-kar-BAZ-e-peen