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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: flushing.

GI: vomiting, cramps, diarrhea, heartburn, nausea.

GU: nephrolithiasis, oxalate nephropathy.

Hemat: hemolysis (in G6PD deficiency), deep vein thrombosis.

Local: pain at SUBQ, IM, or IV sites.

Neuro: fatigue, drowsiness, headache, insomnia.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

US Brand Names

Ascor, Ascorbicap, Cebid, Cecon, Cecore-500, Cemill, Cenolate, Cetane, Cevalin, Cevi-Bid, Flavorcee, Mega-C/A Plus, Ortho/CS, Sunkist

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: vitamins

Pharmacologic Classification: water soluble vitamins

Pharmacokinetics

Absorption: Actively absorbed after oral administration by a saturable process. IV administration results in complete bioavailability.

Distribution: Widely distributed. Crosses the placenta; enters breast milk.

Metabolism/Excretion: Converted to compounds that are excreted by the kidneys.

Half-life: 7.4 hr.

Canadian Brand Names

Apo-C

Time/Action Profile

(response to skeletal and hemorrhagic changes in scurvy)

ROUTEONSETPEAKDURATION
PO, IM, IV, SUBQ2 days–3 wkunknownunknown

Patient/Family Teaching

Pronunciation

as-KOR-bik A-sid