- The extended-release tablets and extended-release oral suspension are NOT interchangeable and should NOT be combined.
Overactive Bladder
- PO (Adults ): 25 mg once daily; may ↑ to 50 mg once daily, if needed, after 48 wk.
Renal Impairment
- PO (Adults ): eGFR 1529 mL/min/m2: 25 mg once daily (max dose = 25 mg/day).
Hepatic Impairment
- PO (Adults ): Moderate hepatic impairment: 25 mg once daily (max dose = 25 mg/day).
Neurogenic Detrusor Overactivity
- PO (Children ≥3 yr and ≥35 kg): Extended-release tablets: 25 mg once daily; may ↑ to 50 mg once daily, if needed, after 48 wk. Extended-release oral suspension (granules): 48 mg once daily; may ↑ to 80 mg once daily, if needed after 48 wk.
- PO (Children ≥3 yr and 22<35 kg): Extended-release oral suspension (granules): 32 mg once daily; may ↑ to 64 mg once daily, if needed after 48 wk.
- PO (Children ≥3 yr and 11<22 kg): Extended-release oral suspension (granules): 24 mg once daily; may ↑ to 48 mg once daily, if needed after 48 wk.
Renal Impairment
- PO (Children ≥3 yr and ≥35 kg): eGFR 1529 mL/min/m2: Extended-release tablets: 25 mg once daily (max dose = 25 mg/day); Extended-release oral suspension (granules): 48 mg once daily (max dose = 48 mg/day).
Renal Impairment
- PO (Children ≥3 yr and 22<35 kg): eGFR 1529 mL/min/m2: Extended-release oral suspension (granules): 32 mg once daily (max dose = 32 mg/day).
Renal Impairment
- PO (Children ≥3 yr and 11<22 kg): eGFR 1529 mL/min/m2: Extended-release oral suspension (granules): 24 mg once daily (max dose = 24 mg/day).
Hepatic Impairment
- PO (Children ≥3 yr and ≥35 kg): Moderate hepatic impairment: Extended-release tablets: 25 mg once daily (max dose = 25 mg/day); Extended-release oral suspension (granules): 48 mg once daily (max dose = 48 mg/day).
Hepatic Impairment
- PO (Children ≥3 yr and 22<35 kg): Moderate hepatic impairment: Extended-release oral suspension (granules): 32 mg once daily (max dose = 32 mg/day).
Hepatic Impairment
- PO (Children ≥3 yr and 11<22 kg): Moderate hepatic impairment: Extended-release oral suspension (granules): 24 mg once daily (max dose = 24 mg/day).
Therapeutic Classification: urinary tract antispasmodics
Pharmacologic Classification: beta-adrenergic agonists
Absorption: 2935% absorbed following oral administration.
Distribution: Widely distributed.
Metabolism/Excretion: Extensively metabolized, 6% excreted unchanged in urine (25 mg dose), remainder excreted in urine and feces as metabolites.
Half-Life: Adults: 50 hr; Children: 2631 hr.