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Indications

High Alert

Unlabeled Uses:

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: BRADYCARDIA, heart block, HF, hypotension, peripheral vasoconstriction.

Derm: rash.

EENT: blurred vision, stuffy nose.

Endo: hyperglycemia, hypoglycemia.

GI: liver enzymes, constipation, diarrhea, drug-induced hepatitis, dry mouth, flatulence, gastric pain, heartburn, nausea, vomiting.

GU: erectile dysfunction, libido, urinary frequency.

MS: arthralgia, back pain, joint pain.

Neuro: fatigue, weakness, anxiety, depression, dizziness, drowsiness, insomnia, memory loss, mental status changes, nervousness, nightmares.

Resp: bronchospasm, PULMONARY EDEMA, wheezing.
Misc: drug-induced lupus syndrome.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

When switching from immediate-release to extended-release product, the same total daily dose can be used

US Brand Names

Kapspargo Sprinkle, Lopressor, Toprol XL

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antianginals, antihypertensives

Pharmacologic Classification: beta blockers

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Crosses the blood-brain barrier, crosses the placenta; small amounts enter breast milk.

Metabolism/Excretion: Mostly metabolized by the liver via the CYP2D6 isoenzyme; the CYP2D6 isoenzyme exhibits genetic polymorphism; 7% of population may be poor metabolizers and may have significantly metoprolol concentrations and an risk of adverse effects.

Half-life: 3–7 hr.

Time/Action Profile

(cardiovascular effects)

ROUTEONSETPEAKDURATION
PO15 minunknown6–12 hr
PO–ERunknown6–12 hr24 hr
IVimmediate20 min5–8 hr

†Maximal effects on BP (chronic therapy) may not occur for 1 wk. Hypotensive effects may persist for up to 4 wk after discontinuation.

Patient/Family Teaching

Pronunciation

me-TOE-proe-lole

Pill Image

metoprolol_tartrate_195_1674.jpg