cosyntropin

REMS

Contraindicated in:

Use Cautiously in:

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Drug-drug:

Corticosteroids, estrogens, and spironolactone alter the results of testing.

(Generic available)

Cortrosyn

A synthetic form of corticotropin (ACTH); stimulates the adrenal gland to primarily produce corticosteroids (hydrocortisone) and a small amount of mineralocorticoids (aldosterone). Action requires intact adrenal responsiveness.

Therapeutic effects:

Therapeutic Classification: diagnostic agents, hormones (adrenocorticotropic)

Pharmacologic Classification: hormones

Absorption: Rapidly absorbed.

Distribution: Well distributed to tissues.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

(effects on plasma cortisol concentrations)

ROUTE	ONSET	PEAK	DURATION
IM, IV	5 min	45–60 min	unknown

KOE-sin-troe-pin